Domestic Box Office Results for 2021 Week 49 (3-Day 12/3/2021 - 12/5/2021)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Encanto | PG | Walt Disney Studios Motion Pictures | $13,147,618 | -51.7% | 3,980 | - | $3,303 | $58,368,259 | 3 |
| - | Ghostbusters: Afterlife | PG-13 | Sony Pictures Entertainment (SPE) | $10,358,451 | -57.2% | 4,059 | -256 | $2,552 | $102,200,045 | 3 |
| - | House of Gucci | R | United Artists Releasing | $7,002,043 | -51.5% | 3,471 | -6 | $2,017 | $33,869,862 | 3 |
| - | Christmas with the Chosen: The Messengers | - | Fathom Entertainment | $4,245,000 | - | 1,700 | 1,700 | $2,497 | $9,145,000 | 2 |
| - | Eternals | PG-13 | Walt Disney Studios Motion Pictures | $4,092,461 | -48.4% | 3,230 | 65 | $1,267 | $156,682,168 | 5 |
| - | Resident Evil: Welcome to Raccoon City | R | Screen Gems | $2,686,027 | -49.5% | 2,803 | - | $958 | $13,204,774 | 3 |
| - | Clifford the Big Red Dog | PG | Paramount Pictures | $1,883,337 | -62.4% | 3,261 | -31 | $578 | $45,811,726 | 5 |
| - | Dune | PG-13 | Warner Bros. | $1,846,463 | -11.2% | 1,217 | -49 | $1,517 | $90,837,778 | 7 |
| - | King Richard | PG-13 | Warner Bros. | $1,227,955 | -62.5% | 2,654 | -648 | $463 | $13,425,506 | 3 |
| - | Sword Art Online: Progressive – Aria of a Starless Night | - | FUNimation Entertainment | $1,050,000 | - | 840 | - | $1,250 | $1,050,000 | 1 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $1,002,743 | -36.6% | 1,234 | -303 | $813 | $210,882,165 | 10 |
| - | No Time to Die | PG-13 | Metro-Goldwyn-Mayer (MGM) | $902,228 | -47.2% | 1,342 | - | $672 | $159,519,266 | 9 |
| - | True to the Game 3 | R | Faith Media Distribution | $573,031 | - | 440 | - | $1,302 | $573,031 | 1 |
| - | Belfast | PG-13 | Focus Features | $533,505 | -44.4% | 1,255 | 127 | $425 | $5,896,495 | 4 |
| - | C’mon C’mon | R | A24 | $462,022 | 49.0% | 565 | 463 | $818 | $1,138,825 | 3 |
| - | The French Dispatch | R | Searchlight Pictures | $372,927 | -40.5% | 425 | 28 | $877 | $15,110,523 | 7 |
| - | Licorice Pizza | R | United Artists Releasing | $241,702 | -30.0% | 4 | - | $60,426 | $779,500 | 2 |
| - | Benedetta | - | IFC Films | $136,839 | - | 201 | - | $681 | $136,839 | 1 |
| - | Spencer | R | NEON | $126,660 | -40.2% | 303 | -43 | $418 | $6,871,618 | 5 |
| - | Ron’s Gone Wrong | PG | 20th Century Studios | $104,438 | -48.4% | 310 | -140 | $337 | $22,888,038 | 7 |
| - | Aline | PG-13 | Roadside Attractions | $102,612 | -37.5% | 72 | 2 | $1,425 | $393,687 | 2 |
| - | L’Arracheuse de temps | - | Entertainment One | $86,000 | -20.2% | 72 | 4 | $1,194 | $559,425 | 3 |
| - | Wolf | R | Focus Features | $82,640 | - | 308 | - | $268 | $82,640 | 1 |
| - | For the Love of Money | R | Freestyle Releasing | $63,691 | -69.9% | 246 | -273 | $259 | $417,777 | 3 |
| - | Tadap | - | FIP | $56,570 | - | 63 | - | $898 | $56,570 | 1 |
| - | Antlers | R | Searchlight Pictures | $43,558 | -24.7% | 180 | 3 | $242 | $10,572,939 | 6 |
| - | Julia | PG-13 | Sony Pictures Classics | $32,381 | -67.7% | 116 | -172 | $279 | $313,405 | 4 |
| - | The Battle at Lake Changjin | - | CMC Pictures | $31,469 | -48.5% | 11 | -5 | $2,861 | $307,049 | 3 |
| - | Anita | - | CMC Pictures | $29,062 | -51.0% | 10 | -2 | $2,906 | $494,308 | 4 |
| - | Try Harder! | - | Greenwich Entertainment | $27,816 | - | 5 | - | $5,563 | $27,816 | 1 |
| - | Drive My Car | - | Janus Films | $27,806 | 101.9% | 4 | 2 | $6,952 | $59,385 | 2 |
| - | My Hero Academia: World Heroes’ Mission | PG-13 | FUNimation Entertainment | $26,745 | -56.2% | 44 | -23 | $608 | $12,238,108 | 6 |
| - | The Addams Family 2 | PG | United Artists Releasing | $26,141 | -36.9% | 107 | - | $244 | $56,467,825 | 10 |
| - | Flee | PG-13 | NEON | $24,794 | - | 4 | - | $6,199 | $24,794 | 1 |
| - | Halloween Kills | R | Universal Pictures | $11,850 | -36.9% | 150 | -15 | $79 | $91,989,305 | 8 |
| - | The Scary of Sixty-First | - | Utopia | $7,808 | - | 1 | - | $7,808 | $7,808 | 1 |
| - | India Sweets and Spices | PG-13 | Bleecker Street Media | $6,984 | -76.5% | 30 | -91 | $233 | $283,643 | 3 |
| - | Bad Luck Banging or Loony Porn | - | Magnolia Pictures | $4,868 | -36.0% | 7 | 2 | $695 | $32,174 | 3 |
| - | Kurt Vonnegut: Unstuck in Time | - | IFC Films | $4,368 | -28.7% | 14 | -16 | $312 | $57,689 | 3 |
| - | The Rescue | PG | Greenwich Entertainment | $3,854 | 15.4% | 8 | -6 | $482 | $1,057,657 | 9 |
| - | Writing with Fire | - | Music Box Films | $3,477 | 1.6% | 8 | 4 | $435 | $6,900 | 2 |
| - | Une révision | - | Entertainment One | $1,925 | -39.6% | 7 | -1 | $275 | $155,577 | 5 |
| - | I Was a Simple Man | - | Strand Releasing | $1,570 | 829.0% | 1 | - | $1,570 | $12,120 | 3 |
| - | The Feast | - | IFC Films | $700 | -39.5% | 2 | -5 | $350 | $7,972 | 3 |
| - | What Do We See When We Look at the Sky? | - | MUBI | $408 | -67.9% | 3 | -1 | $136 | $12,501 | 4 |
| - | Luzzu | - | Kino Lorber | $349 | 35.8% | 2 | - | $175 | $17,433 | 8 |
| - | Shiva Baby | - | Utopia | $43 | -69.9% | 1 | - | $43 | $158,614 | 26 |