Wain was director/co-writer/producer of the anthology comedy inspired by The Ten Commandments, The Ten (2007), produced (in part) and co-starring Paul Rudd, and with Adam Brody, Rob Corddry, Famke Janssen, Gretchen Mol, Oliver Platt, Winona Rudd,
Liev Schreiber, Justin Theroux and Jessica Alba, and was released by ThinkFilm after launching at the Sundance Film Festival.
Wain had his first comedy hit as director/co-writer with Role Models (2008), co-written (in part) and co-starring Paul Rudd, with Seann William Scott, Christopher Mintz-Plasse, Elizabeth Banks, Jane Lynch, Ken Jeong,
Keegan-Michael Key, Jorma Taccone and Louis C.K., produced by Relativity Media/Stuber-Parent Productions and released by Universal Pictures to a $92.4 million global gross. Wain was director/co-writer/producer of the failed Universal Pictures comedy, Wanderlust (2012), co-written and produced (in part) by Ken Marino, starring Paul Rudd (who also was a producer), Jennifer Aniston, Justin Theroux, Malin Akerman, Kathryn Hahn, Lauren Ambrose and Alan Alda, produced (in part) by Apatow Productions/Relativity Media and distributed by Universal Pictures for a poor $24.2 million (based on estimated costs).
David Wain was director/co-writer (with co-writer Michael Showalter, who also produced) of the rom-com satire,
They Came Together (2014), starring Paul Rudd, Amy Poehler, Christopher Meloni, Max Greenfield, Bill Hader, Ellie Kemper, Melanie Lynskey and Ed Helms, and which was released by Lionsgate after premiering at the Sundance Film Festival. Wain was director/co-writer (with producer and cast member Ken Marino)/producer—and made an on-screen appearance--for the comedy,
Gail Daughtry and the Celebrity Sex Pass (2026), co-starring Zoey Deutch,
Jon Hamm, John Slattery, Miles Gutierrez-Riley,
Ben Wang, and Sabina Impacciatore, produced by Likely Story/Oval-5 and distributed in wide release by Sony Pictures Classics after launching at the Sundance Film Festival.