Domestic Box Office Results for 2021, all ratings and all genres
| Rank | Title | Distributor | Release Date | Year | Rating | Genre | Total To-Date | Total In Year |
|---|---|---|---|---|---|---|---|---|
| 1 | Spider-Man: No Way Home | Sony Pictures Entertainment (SPE) | Dec 17, 2021 | 2021 | PG-13 | Action | $804,793,477 | $635,738,195 |
| 2 | Shang-Chi and the Legend of the Ten Rings | Walt Disney Studios Motion Pictures | Sep 3, 2021 | 2021 | PG-13 | Action | $224,543,292 | $224,543,292 |
| 3 | Venom: Let There Be Carnage | Sony Pictures Entertainment (SPE) | Oct 1, 2021 | 2021 | PG-13 | Action | $213,550,366 | $212,650,933 |
| 4 | F9: The Fast Saga | Universal Pictures | Jun 25, 2021 | 2021 | PG-13 | Action | $173,005,945 | $173,005,945 |
| 5 | Eternals | Walt Disney Studios Motion Pictures | Nov 5, 2021 | 2021 | PG-13 | Action | $164,870,234 | $164,743,388 |
| 6 | No Time to Die | Metro-Goldwyn-Mayer (MGM) | Oct 8, 2021 | 2021 | PG-13 | Action | $160,891,007 | $160,772,007 |
| 7 | A Quiet Place Part II | Paramount Pictures | May 28, 2021 | 2021 | PG-13 | Horror | $160,072,261 | $160,072,261 |
| 8 | Ghostbusters: Afterlife | Sony Pictures Entertainment (SPE) | Nov 19, 2021 | 2021 | PG-13 | Adventure | $129,360,575 | $123,924,125 |
| 9 | Free Guy | 20th Century Studios | Aug 13, 2021 | 2021 | PG-13 | Comedy | $121,626,598 | $121,626,598 |
| 10 | Godzilla vs. Kong | Warner Bros. | Mar 31, 2021 | 2021 | PG-13 | Action | $99,244,744 | $99,244,744 |
| 11 | Sing 2 | Universal Pictures | Dec 22, 2021 | 2021 | PG | Animation | $161,190,990 | $95,462,985 |
| 12 | Dune: Part One | Warner Bros. | Oct 22, 2021 | 2021 | PG-13 | Sci-Fi | $94,556,598 | $93,478,031 |
| 13 | Halloween Kills | Universal Pictures | Oct 15, 2021 | 2021 | R | Horror | $92,002,155 | $92,002,155 |
| 14 | Encanto | Walt Disney Studios Motion Pictures | Nov 24, 2021 | 2021 | PG | Animation | $96,093,622 | $91,895,165 |
| 15 | Cruella | Walt Disney Studios Motion Pictures | May 28, 2021 | 2021 | PG-13 | Comedy | $86,103,234 | $86,103,234 |
| 16 | Space Jam: A New Legacy | Warner Bros. | Jul 16, 2021 | 2021 | PG | Animation | $75,633,203 | $75,633,203 |
| 17 | The Conjuring: The Devil Made Me Do It | Warner Bros. | Jun 4, 2021 | 2021 | R | Horror | $65,513,102 | $65,513,102 |
| 18 | Candyman | Universal Pictures | Aug 27, 2021 | 2021 | R | Horror | $61,186,570 | $61,186,570 |
| 19 | The Boss Baby 2: Family Business | Universal Pictures | Jul 2, 2021 | 2021 | PG | Animation | $57,300,280 | $57,300,280 |
| 20 | The Addams Family 2 | United Artists Releasing | Oct 1, 2021 | 2021 | PG | Animation | $56,489,153 | $56,489,153 |
| 21 | The Suicide Squad | Warner Bros. | Aug 6, 2021 | 2021 | R | Action | $55,795,457 | $55,795,457 |
| 22 | Raya and the Last Dragon | Walt Disney Studios Motion Pictures | Mar 5, 2021 | 2021 | PG | Animation | $54,723,032 | $54,723,032 |
| 23 | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train | FUNimation Entertainment | Apr 23, 2021 | 2021 | R | Action | $49,505,008 | $49,505,008 |
| 24 | House of Gucci | United Artists Releasing | Nov 24, 2021 | 2021 | R | Biography | $53,809,574 | $49,453,205 |
| 25 | Clifford the Big Red Dog | Paramount Pictures | Nov 10, 2021 | 2021 | PG | Family | $48,947,356 | $48,947,356 |