Domestic Box Office Results for 2021 Week 42 (3-Day 10/15/2021 - 10/17/2021)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Halloween Kills | R | Universal Pictures | $49,404,980 | - | 3,705 | - | $13,335 | $49,404,980 | 1 |
| - | No Time to Die | PG-13 | Metro-Goldwyn-Mayer (MGM) | $23,792,118 | -56.9% | 4,407 | - | $5,399 | $99,002,672 | 2 |
| - | Venom: Let There Be Carnage | PG-13 | Sony Pictures Entertainment (SPE) | $16,501,406 | -48.0% | 4,013 | -212 | $4,112 | $168,079,076 | 3 |
| - | The Addams Family 2 | PG | United Artists Releasing | $7,064,531 | -30.2% | 3,607 | -600 | $1,959 | $42,142,794 | 3 |
| - | The Last Duel | R | 20th Century Studios | $4,759,151 | - | 3,065 | - | $1,553 | $4,759,151 | 1 |
| - | Shang-Chi and the Legend of the Ten Rings | PG-13 | Walt Disney Studios Motion Pictures | $3,321,610 | -22.9% | 2,300 | -500 | $1,444 | $217,852,469 | 7 |
| - | Honsla Rakh | - | Independent | $706,000 | - | 100 | - | $7,060 | $706,000 | 1 |
| - | Free Guy | PG-13 | 20th Century Studios | $645,712 | -47.9% | 915 | -580 | $706 | $120,779,261 | 10 |
| - | Lamb | R | A24 | $543,004 | -45.7% | 865 | 282 | $628 | $2,037,730 | 2 |
| - | Most Eligible Bachelor | - | GA2 Pictures | $470,000 | - | 195 | - | $2,410 | $470,000 | 1 |
| - | Candyman | R | Universal Pictures | $441,500 | -37.8% | 1,012 | -141 | $436 | $60,785,465 | 8 |
| - | The Rescue | PG | Greenwich Entertainment | $382,200 | 482.7% | 561 | 552 | $681 | $469,067 | 2 |
| - | Dear Evan Hansen | PG-13 | Universal Pictures | $380,625 | -62.4% | 974 | -953 | $391 | $14,574,385 | 4 |
| - | The Many Saints of Newark | R | Warner Bros. | $171,004 | -88.0% | 502 | -2,679 | $341 | $7,578,056 | 3 |
| - | Jungle Cruise | PG-13 | Walt Disney Studios Motion Pictures | $109,118 | -49.3% | 235 | -210 | $464 | $116,753,284 | 12 |
| - | Titane | R | NEON | $90,207 | -57.6% | 112 | -362 | $805 | $1,297,695 | 3 |
| - | Cry Macho | PG-13 | Warner Bros. | $71,495 | -50.9% | 235 | -235 | $304 | $10,099,217 | 5 |
| - | After We Fell | R | Vertical Entertainment | $59,703 | -56.1% | 126 | -23 | $474 | $2,122,133 | 6 |
| - | Monster Family 2 | PG | Viva Pictures | $57,501 | - | 97 | - | $593 | $57,501 | 1 |
| - | Bergman Island | R | IFC Films | $55,964 | - | 115 | - | $487 | $55,964 | 1 |
| - | The Jesus Music | PG-13 | Lionsgate | $38,249 | -75.7% | 103 | -167 | $371 | $991,719 | 3 |
| - | Hard Luck Love Song | R | Roadside Attractions | $36,718 | - | 172 | - | $213 | $36,718 | 1 |
| - | Mass | PG-13 | Bleecker Street Media | $28,147 | 108.7% | 37 | 33 | $761 | $49,576 | 2 |
| - | I’m Your Man | R | Bleecker Street Media | $28,050 | -48.3% | 103 | -19 | $272 | $231,079 | 4 |
| - | My Country, My Parents | - | CMC Pictures | $24,890 | -66.9% | 24 | -27 | $1,037 | $144,129 | 2 |
| - | The Eyes of Tammy Faye | PG-13 | Searchlight Pictures | $22,459 | -51.2% | 55 | -70 | $408 | $2,366,463 | 5 |
| - | Malignant | R | Warner Bros. | $18,043 | -83.9% | 81 | -85 | $223 | $13,334,116 | 6 |
| - | Respect | PG-13 | Metro-Goldwyn-Mayer (MGM) | $15,331 | -29.4% | 45 | -22 | $341 | $24,272,382 | 10 |
| - | The Boss Baby 2: Family Business | PG | Universal Pictures | $12,850 | -11.9% | 295 | -33 | $44 | $57,296,105 | 16 |
| - | The Alpinist | PG-13 | Roadside Attractions | $8,708 | -27.3% | 22 | -6 | $396 | $822,644 | 6 |
| - | Copshop | R | Open Road Films | $6,765 | -86.5% | 24 | -40 | $282 | $5,212,655 | 5 |
| - | Wife of a Spy | - | Kino Lorber | $3,688 | -57.4% | 12 | -9 | $307 | $54,238 | 5 |
| - | Golden Voices | - | Music Box Films | $3,213 | -48.1% | 8 | 1 | $402 | $13,118 | 2 |
| - | Introducing, Selma Blair | - | Strand Releasing | $3,157 | - | 3 | - | $1,052 | $3,157 | 1 |
| - | Luzzu | - | Kino Lorber | $2,394 | - | 1 | - | $2,394 | $2,394 | 1 |
| - | Azor | - | MUBI | $1,954 | -35.7% | 8 | -2 | $244 | $45,084 | 6 |
| - | Tango Shalom | PG-13 | Vision Films | $1,823 | -47.9% | 5 | -3 | $365 | $97,718 | 7 |
| - | Breathless (2021 Re-release) | - | Rialto Pictures | $1,671 | -62.6% | 3 | -1 | $557 | $35,551 | 4 |
| - | Old Henry | - | Shout! Factory | $1,195 | -71.2% | 4 | -8 | $299 | $38,389 | 3 |
| - | The Lost Leonardo | PG-13 | Sony Pictures Classics | $1,007 | -84.9% | 8 | -8 | $126 | $438,646 | 10 |
| - | Falling for Figaro | - | IFC Films | $984 | -80.0% | 10 | -15 | $98 | $31,787 | 3 |
| - | On Broadway | - | Kino Lorber | $570 | -59.2% | 4 | -7 | $143 | $74,447 | 8 |
| - | Nine Days | R | Sony Pictures Classics | $394 | -62.4% | 3 | - | $131 | $693,900 | 12 |
| - | Who You Think I Am | - | Cohen Media Group | $391 | -76.7% | 3 | -2 | $130 | $45,265 | 7 |
| - | Language Lessons | - | Shout! Factory | $367 | -78.1% | 2 | -5 | $184 | $73,257 | 6 |
| - | 12 Mighty Orphans | PG-13 | Sony Pictures Entertainment (SPE) | $320 | -79.4% | 3 | -2 | $107 | $3,689,723 | 19 |
| - | Ema | R | Music Box Films | $216 | 242.9% | 1 | - | $216 | $53,093 | 10 |
| - | Little Girl | - | Music Box Films | $187 | -77.8% | 2 | -3 | $94 | $9,097 | 5 |