Domestic Box Office Results for 2021 Week 21 (3-Day 5/21/2021 - 5/23/2021)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| - | Spiral | R | Lionsgate | $4,595,320 | -47.5% | 2,991 | 180 | $1,536 | $15,873,020 | 2 |
| - | Wrath of Man | R | United Artists Releasing | $2,978,090 | -19.6% | 3,007 | - | $990 | $18,852,122 | 3 |
| - | Those Who Wish Me Dead | R | Warner Bros. | $1,925,080 | -32.0% | 3,379 | 191 | $570 | $5,626,737 | 2 |
| - | Raya and the Last Dragon | PG | Walt Disney Studios Motion Pictures | $1,666,739 | -2.0% | 2,375 | 90 | $702 | $48,306,284 | 12 |
| - | Godzilla vs. Kong | PG-13 | Warner Bros. | $1,404,857 | -7.6% | 2,552 | 68 | $550 | $95,975,816 | 9 |
| - | Demon Slayer: Kimetsu no Yaiba – The Movie: Mugen Train | R | FUNimation Entertainment | $1,374,851 | -29.7% | 1,878 | -36 | $732 | $44,976,418 | 5 |
| - | Mortal Kombat | R | Warner Bros. | $950,036 | -28.5% | 2,386 | -79 | $398 | $36,702,635 | 5 |
| - | Scoob! | PG | Warner Bros. | $850,000 | - | 2,500 | - | $340 | $850,000 | 1 |
| - | Dream Horse | PG | Bleecker Street Media | $794,741 | - | 1,254 | - | $634 | $794,741 | 1 |
| - | Finding You | PG | Roadside Attractions | $672,111 | -27.0% | 1,447 | 135 | $464 | $1,907,607 | 2 |
| - | Profile | R | Focus Features | $510,320 | -30.1% | 2,104 | 71 | $243 | $1,517,355 | 2 |
| - | Tom & Jerry | PG | Warner Bros. | $346,883 | 0.4% | 1,623 | -34 | $214 | $45,492,539 | 13 |
| - | Here Today | PG-13 | Stage 6 Films | $330,710 | -38.2% | 1,230 | 30 | $269 | $2,460,294 | 3 |
| - | The Unholy | PG-13 | Screen Gems | $327,002 | -12.1% | 745 | -114 | $439 | $15,223,292 | 8 |
| - | Nobody | R | Universal Pictures | $314,790 | -17.1% | 1,464 | -89 | $215 | $25,745,110 | 9 |
| - | Separation | R | Open Road Films | $200,925 | -39.4% | 704 | -449 | $285 | $4,392,451 | 4 |
| - | The Croods: A New Age | PG | Universal Pictures | $145,215 | -17.1% | 1,054 | -43 | $138 | $58,204,105 | 27 |
| - | New Order | R | NEON | $144,533 | - | 236 | - | $612 | $144,533 | 1 |
| - | Final Account | PG-13 | Focus Features | $139,985 | - | 308 | - | $454 | $139,985 | 1 |
| - | The Dry | R | IFC Films | $119,364 | - | 186 | - | $642 | $119,364 | 1 |
| - | Top Gun (2021 Re-release) | PG | Paramount Pictures | $62,566 | -70.9% | 56 | -97 | $1,117 | $384,518 | 2 |
| - | The Girl Who Believes in Miracles | PG | Atlas Distribution Company | $43,700 | -34.5% | 322 | -95 | $136 | $3,119,775 | 8 |
| - | The Djinn | R | IFC Films | $42,222 | -16.1% | 44 | 3 | $960 | $99,364 | 2 |
| - | The Courier | PG-13 | Roadside Attractions | $41,892 | -17.4% | 108 | -29 | $388 | $6,535,282 | 10 |
| - | Minari | PG-13 | A24 | $39,752 | -11.8% | 149 | -69 | $267 | $3,110,580 | 15 |
| - | Four Good Days | R | Vertical Entertainment | $30,132 | -56.9% | 170 | -156 | $177 | $827,860 | 4 |
| - | Together Together | R | Bleecker Street Media | $18,891 | -51.1% | 83 | -82 | $228 | $1,401,679 | 5 |
| - | The Truffle Hunters | PG-13 | Sony Pictures Classics | $17,553 | -19.4% | 51 | -15 | $344 | $278,323 | 7 |
| - | The Killing of Two Lovers | R | NEON | $16,115 | -36.5% | 36 | 2 | $448 | $50,889 | 2 |
| - | The War with Grandpa | PG | 101 Studios | $15,018 | 13.4% | 62 | -8 | $242 | $21,262,026 | 33 |
| - | Riders of Justice | - | Magnolia Pictures | $14,155 | -8.3% | 18 | 1 | $786 | $29,596 | 2 |
| - | The Father | PG-13 | Sony Pictures Classics | $12,390 | -26.8% | 46 | -29 | $269 | $2,032,705 | 11 |
| - | The Swimming Pool (2021 Re-release) | - | Rialto Pictures | $9,444 | 144.2% | 4 | 3 | $2,361 | $18,120 | 2 |
| - | The Resort | - | Vertical Entertainment | $8,359 | -10.3% | 26 | 7 | $322 | $188,987 | 4 |
| - | Cliff Walkers | - | CMC Pictures | $7,052 | -33.1% | 15 | -4 | $470 | $142,727 | 4 |
| - | Mission Stories | - | Excel Entertainment | $7,026 | -44.7% | 26 | -17 | $270 | $75,457 | 3 |
| - | The Paper Tigers | PG-13 | Well Go USA Entertainment | $6,703 | -30.7% | 12 | -18 | $559 | $88,746 | 3 |
| - | My Love | - | CMC Pictures | $6,421 | -44.1% | 9 | -9 | $713 | $78,784 | 3 |
| - | French Exit | R | Sony Pictures Classics | $5,226 | -12.4% | 8 | -8 | $653 | $696,138 | 8 |
| - | Shiva Baby | - | Utopia | $4,365 | 45.6% | 7 | 1 | $624 | $111,464 | 8 |
| - | The Perfect Candidate | - | Music Box Films | $3,803 | 36.1% | 14 | 9 | $272 | $8,414 | 2 |
| - | About Endlessness | - | Magnolia Pictures | $2,301 | -35.8% | 6 | -6 | $384 | $30,979 | 4 |
| - | Gunda | G | NEON | $2,137 | -65.3% | 14 | -21 | $153 | $59,451 | 6 |
| - | There Is No Evil | - | Kino Lorber | $1,335 | -58.8% | 2 | -5 | $668 | $6,568 | 2 |
| - | The Human Factor | PG-13 | Sony Pictures Classics | $1,312 | -80.4% | 12 | -43 | $109 | $34,985 | 3 |
| - | Mainstream | R | IFC Films | $1,179 | -64.7% | 10 | -12 | $118 | $33,293 | 3 |
| - | State Funeral | - | MUBI | $1,082 | -29.8% | 1 | -1 | $1,082 | $10,995 | 3 |
| - | Ghost Master | - | Indican Pictures | $333 | -92.1% | 2 | - | $167 | $5,395 | 2 |
| - | Lamb of God: The Concert Film | - | Excel Entertainment | $185 | -60.1% | 2 | -5 | $93 | $744,699 | 9 |
| - | Six Minutes to Midnight | PG-13 | IFC Films | $140 | -78.1% | 1 | -4 | $140 | $132,492 | 9 |