A story about a beautiful street musician suffering from memory loss and a disheartened neuroscientist intent on helping her, bringing together the city of New Orleans and the jazz that made it famous.
An uptight and by-the-book cop (Reese Witherspoon) tries to protect the outgoing widow (Sofia Vergara) of a drug boss as they race through Texas pursued by crooked cops and murderous gunmen.
When an unseen enemy threatens mankind by taking over their bodies and erasing their memories, Melanie Stryder risks everything to protect the people she cares about.
After watching their respective partners die, a New Orleans hitman and a Washington, D.C. detective form an alliance in order to bring down their common enemy.